The concept for the Fugue project emerged as a spin-off from the work on the Art Council England-funded prototype for Algorithmica , a large-scale art work partly inspired by the immune system. When Dr. Bentley, a specialist in artificial immunology and collaborator on the project, showed the visual model produced for the art work to some practicing immunologists, their strong interest suggested the possibility of developing a new method for the visualisation of the immune system, giving equal weight to art and science.

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